• LMS Login
Phone: 0407 011 730
Lymphoedema Education Solutions
  • Home
  • Courses
    • Face to face
    • LES online
    • KLOSE online
  • About
    • About LES
    • Trainers
    • Upcoming dates
    • Resources
    • Lymphactive Products
    • Access Lymphoedema Links
  • Contact
  • Sign Up
  • Search
  • Menu Menu

Hot off the Press February 2023

We have collated some great articles and material published over the last month. Click on the links below to read the  abstract or download the full paper.

Anatomy / Physiology /Pathophysiology

Lymphatic endothelial cell RXRα is critical for 9-cis-retinoic acid-mediated lymphangiogenesis and prevention of secondary lymphedema - click for abstract

Lymphatic endothelial cell RXRα is critical for 9-cis-retinoic acid-mediated lymphangiogenesis and prevention of secondary lymphedema

Cynthia Sung, Wan Jiao, Sun Young Park, Michael Cooper, Antoun Bouz, Dahae Choi, Eunson Jung, Gene Kim, Young Kwon Hong, Alex K Wong. FASEB J. 2023 Jan;37(1):e22674.
Secondary lymphedema is a debilitating disease characterized by abnormal soft tissue swelling and caused by lymphatic system dysfunction. Despite a high prevalence of secondary lymphedema after cancer treatments, current management is supportive and there are no approved therapeutic agents that can thwart disease progression. We have previously demonstrated that 9-cis-retinoic acid (9-cisRA) has the potential to be repurposed for lymphedema as it mitigates disease by promoting lymphangiogenesis at the site of lymphatic injury. Although the efficacy of 9-cisRA has been demonstrated in previous studies, the mechanism of action is not completely understood. In this study, we demonstrate that when RXRα is specifically deleted in lymphatic endothelial cells, 9-cisRA fails to induce lymphangiogenesis in vitro and prevent pathologic progression of postsurgical lymphedema in vivo. These findings demonstrate that downstream nuclear receptor RXRα plays a critical role in the therapeutic efficacy of 9-cisRA in postsurgical lymphedema.

Physiological Roles of Lymph Flow-Mediated Nitric Oxide in Lymphatic System - click for abstract

Physiological Roles of Lymph Flow-Mediated Nitric Oxide in Lymphatic System

Toshio Ohhashi, Yoshiko Kawai, Daisuke Maejima, Moyuru Hayashi, Tomomi Watanabe-Asaka. Lymphat Res Biol. 2022 Dec 26
It is known that nitric oxide (NO) is a gas and synthesized from l-arginine by the NO synthase (NOS) in vascular endothelial cells. The diffused NO activates the guanosine monophosphate, which initiates a series of intracellular events, leading to physiological response such as vasodilation. There are three different types of NOS, namely endothelial constitutive NOS (ecNOS), neuronal NOS (nNOS), and cytokine-inducible NOS (iNOS). The ecNOS and nNOS are expressed constitutively at low levels and can be activated rapidly by an increase in cytoplasmic calcium ions. In contrast, the iNOS is induced when macrophages are activated by cytokine, resulting in the induction of pathophysiological effects. Lymph flow is known to stimulate the release of NO from lymphatic endothelial cells (LEC) and then produce the relaxation of lymphatic smooth muscle cells. The NO also plays a key role in the control of lymphatic pump activity in vivo. Many studies have shown the NO-mediated findings in various kinds of lymph vessels. However, there is no or little study to demonstrate the effects of lymph flow on the molecular expression of ecNOS mRNA and the protein. In addition, little study is available for clarifying the relationship between NO and sympathetic nerve fibers in the regulation of lymph transport and production. Therefore, in this review, the experimental findings of lymph flow-mediated increases in the ecNOS mRNA and the protein in LEC are demonstrated in detail. In addition, the roles of NO and aminergic nerve fibers in the physiological control system of lymph transport and production are discussed.

The Vicious Circle of Stasis, Inflammation, and Fibrosis in Lymphedema - click for abstract

The Vicious Circle of Stasis, Inflammation, and Fibrosis in Lymphedema

Stav Brown, Joseph H Dayan, Raghu P Kataru, Babak J Mehrara. Plast Reconstr Surg. 2023 Feb 1;151(2):330e-341e.
Lymphedema is a progressive disease of the lymphatic system arising from impaired lymphatic drainage, accumulation of interstitial fluid, and fibroadipose deposition. Secondary lymphedema resulting from cancer treatment is the most common form of the disease in developed countries, affecting 15% to 40% of patients with breast cancer after lymph node dissection. Despite recent advances in microsurgery, outcomes remain variable and, in some cases, inadequate. Thus, development of novel treatment strategies is an important goal. Research over the past decade suggests that lymphatic injury initiates a chronic inflammatory response that regulates the pathophysiology of lymphedema. T-cell inflammation plays a key role in this response. In this review, the authors highlight the cellular and molecular mechanisms of lymphedema and discuss promising preclinical therapies.

The Lymphatic System, Lymphoedema, and Medical Curricula-Survey of Australian Medical Graduates

Natalie Kruger, Melanie L Plinsinga, Rhian Noble-Jones, Neil B. Piller, Vaughan L. Keeley, Sandra C Hayes. Cancers (Basel). 2022 Dec 16;14(24):6219

Download full paper

Keratinocytes coordinate inflammatory responses and regulate development of secondary lymphedema

Hyeung Ju Park, Raghu P Kataru, Jinyeon Shin, Gabriela D Garc A Nores, Elizabeth M Encarnacion, Mark G Klang, Elyn Riedel, Michelle Coriddi, Joseph H Dayan, Babak J Mehrara. bioRxiv. 2023 Jan 21:2023.01.20.52493
 

Download full paper

Prevalence and Risk Factors

Association of lower extremity lymphedema with pelvic floor functions, sleep quality, kinesiophobia, body image in patients with gynecological cancers - click for abstract

Association of lower extremity lymphedema with pelvic floor functions, sleep quality, kinesiophobia, body image in patients with gynecological cancers

Hanife Abakay, Hanife Dogan, Ayşe Atilabey Güç, Havva Talay Çalış. Women Health. 2022 Dec 14:1-8.
The aim was to investigate the relationship between lower extremity lymphedema and pelvic floor functions, sleep quality, kinesiophobia, body image in patients with gynecological cancer the effect of lymphedema severity on pelvic floor dysfunction (PFD), sleep quality, fear of movement, and body image in patients with lower extremity lymphedema after gynecologic cancer. A total of 103 patients (52 patients with lymphedema and 51 patients without lymphedema) after gynecologic cancer surgery were included in March-June 2022. Bilateral circumferential measurements were taken with a tape measure at different levels to create groups. These measurements determined limb volumes by summing segment volumes derived from the truncated cone formula. For data collection, all patients were presented with the Gynecologic Cancer Lymphedema Questionnaire (GCLQ), the Global Pelvic Floor Bother Questionnaire (GPFBQ), the Pittsburgh Sleep Quality Index (PSQI), the Tampa Scale of Kinesiophobia (TSK) and the Body Image Scale (BIS) one time. The severity of lymphedema symptoms was quite high in patients with lymphedema (GCLQ Total: 13.6) (p < .05). Patients with lymphedema had higher GCLQ total scores, GPFBQ1 (stress urinary incontinence), GPFBQ4 (urge urinary incontinence), GPFBQ8 (fecal incontinence), kinesiophobia and, body image scores than patients without lymphedema (p < .05). The sleep quality levels of patients with lymphedema and patients without lymphedema were similar (p > .05). A significant negative correlation was found between GLCQ total score and body image (p < .05). There was a positive correlation between kinesiophobia and pelvic floor symptoms and a negative correlation between kinesiophobia and body image (p < .05). In this study, it was observed that in patients who developed lymphedema after gynecologic cancer surgery, pelvic floor symptoms and kinesiophobia increased and the severity of lymphedema negatively affected body image. Reducing lymphedema in these patients may improve pelvic floor health, mobility, and body image.

Prevention of breast cancer-related lymphoedema: Quality of clinical practice guidelines and variations in recommendations - click for abstract

Prevention of breast cancer-related lymphoedema: Quality of clinical practice guidelines and variations in recommendations

Mingzhen Li, Boxuan Liu, Cheng Chen, Huan Liu, Shaohua He, Weihua Sun, Qiang Yan, Xiaohua Rao, Yinghui Jin, Liming Tan. Int J Nurs Pract. 2022 Dec 21:e13127.

Aim: We aimed to evaluate the quality of clinical practice guidelines (CPGs) for breast cancer related lymphoedema (BCRL) and compare the similarities and differences in recommendations.

Background: Many CPGs of BCRL have been developed; however, their recommendations and quality are controversial.

Methods: Relevant papers were retrieved from electronic databases, professional associations and guideline development organizations, from 1 January 2015 to 30 September 2021. The Appraisal of Guidelines Research and Evaluation (AGREE) II instrument was used to evaluate the quality of the guidelines. Intraclass correlation coefficient (ICC) analysis was used to evaluate the overall consistency among evaluators.

Results: Eight CPGs were included. The ICC values evaluation for CPGs ranged from 0.76 to 0.95, with good consensus among evaluators. The highest median score was 68.75% (61.46, 72.22%) for clarity, and the lowest was 37.50% (25.78, 51.30%) for applicability. The NICE, ACS/ACSO and APTA CPGs were rated well in most areas. Professional health education, individualized exercise programme and regular surveillance are the main methods to prevent lymphoedema.

Conclusion: In the past 6 years, the quality of BCRL guidelines has varied greatly, especially in the domains of rigour and applicability. Interrater agreement was excellent, but recommendation showed some inconsistencies in the details.

Association between Immediate Breast Reconstruction and the Development of Breast Cancer-Related Lymphedema - click for abstract

Association between Immediate Breast Reconstruction and the Development of Breast Cancer-Related Lymphedema

Hong Bae Jeon, Ji Hyuk Jung, Sang Hee Im, Yong Bae Kim, Jee Suk Chang, Seung Yong Song, Dae Hyun Lew, Tai Suk Roh, Won Jai Lee, Dong Won Lee. Plast Reconstr Surg. 2023 Feb 1;151(2):214e-222e.
BACKGROUND: With the increasing number of patients undergoing immediate breast reconstruction after mastectomy, the impact of immediate breast reconstruction on the risk of breast cancer-related lymphedema has become an emerging area of interest. This study aimed to identify the association between immediate breast reconstruction and postoperative lymphedema.
METHODS: A retrospective cohort study was conducted from 2006 to 2016 with 5900 consecutive patients who underwent mastectomy for primary breast cancer with or without immediate breast reconstruction. After excluding patients with synchronous contralateral breast cancer, lymphedema before mastectomy, history of procedures performed in the axillary region, and follow-up data of less than 1 year, the cumulative incidence of lymphedema after immediate breast reconstruction and after no reconstruction was calculated and compared using multivariate Cox regression analysis.
RESULTS: Overall, 5497 patients (mean age, 51.7 years) were included, and 630 developed lymphedema. The 5-year cumulative incidence rate of lymphedema was significantly reduced in patients who underwent immediate breast reconstruction versus control patients (9.6% versus 12.2%; P = 0.02). In the multivariate analysis, immediate breast reconstruction status (hazard ratio, 0.75; 95% confidence interval, 0.56 to 0.99; P = 0.042) was an independent predictor for lymphedema. Similar significant associations were observed in the subgroup analyses of patients with a body mass index less than 30 kg/m2 (P = 0.024), in those with fewer than 10 dissected lymph nodes (P = 0.042), or in those with adjuvant radiotherapy (P = 0.048).
CONCLUSIONS: Immediate breast reconstruction was associated with a reduced risk of lymphedema. These results may be used for predicting the development of lymphedema following breast reconstruction

Prevention of lymphoedema after axillary clearance by external compression sleeves PLACE randomised trial results. Effects of high BMI

Nigel J Bundred, Emma Barrett, Chriss Todd, Julie Morris, Donna Watterson, Arnie Purushotham, Katie Riches, Abigail Evans, Anthony Skene, Vaughan L. Keeley, Investigators of BEA/PLACE studies. Cancer Med. 2022 Dec 12. 

Download full paper

Do Patient-Reported Upper-Body Symptoms Predict Breast Cancer-Related Lymphoedema: Results from a Population-Based, Longitudinal Breast Cancer Cohort Study

Sandra C Hayes, Matthew Dunn, Melanie L Plinsinga, Hildegard Reul-Hirche, Yumeng Ren, E-Liisa Laakso, Melissa A Troester. Cancers (Basel). 2022 Dec 5;14(23):5998.

Download full paper

Risk factors for lower extremity lymphedema after surgery in cervical and endometrial cancer

Joongyo Lee, Hwa Kyung Byun, Sang Hee Im, Won Jeong Son, Yun Ho Roh, Yong Bae Kim. J Gynecol Oncol. 2022 Dec 19

Download full paper

The prevention and treatment of breast cancer- related lymphedema: A review
Maureen P McEvoy, Ameer Gomberawalla, Mark Smith, Francesco M Boccardo, Dennis Holmes, Risal Djohan, Paul Thiruchelvam, Suzanne Klimberg, Jill Dietz, Sheldon Feldman. Front Oncol. 2022 Dec 6;12:1062472.

Download full paper

Assessment

The agreement between three classification systems used to grade the severity of lymphedema in patients with upper and lower extremity lymphedema: A retrospective study - click for abstract

The agreement between three classification systems used to grade the severity of lymphedema in patients with upper and lower extremity lymphedema: A retrospective study

Ertan Şahinoğlu, Gülbin Ergin, Didem Karadibak. Physiother Theory Pract. 2022 Dec 25:1-6
BACKGROUND: Several classification systems are used to grade the severity of lymphedema. Their agreement with each other has not been reported.
OBJECTIVE: To evaluate the agreement between the American Physical Therapy Association (APTA) criteria, the criteria of Ramos et al., and the International Society of Lymphology (ISL) criteria in patients with upper and lower extremity lymphedema.
METHODS: A total of 156 patients (63 and 93 patients with upper and lower extremity lymphedema, respectively) were included. The circumference measurements and limb volume were measured. The severity of lymphedema of the patients was classified as mild, moderate, and severe lymphedema using the APTA criteria, the criteria of Ramos et al., and the ISL criteria. The agreement between the classification systems was assessed with Krippendorff’s alpha.
RESULTS: An acceptable and poor agreement were found between the criteria in upper (Krippendorff’s alpha > 0.667) and lower extremity lymphedema (Krippendorff’s alpha < 0.667), respectively. In pairwise comparisons, an acceptable agreement was found among each comparison in upper extremity lymphedema (Krippendorff's alpha > 0.667), and a poor agreement was found among each comparison in lower extremity lymphedema (Krippendorff’s alpha < 0.667) except between the APTA criteria and the criteria of Ramos et al (Krippendorff's alpha > 0.667).
CONCLUSIONS: Patients with upper extremity lymphedema classified according to these criteria can be assumed to be samples of the same population; however, patients with lower extremity lymphedema graded according to the ISL criteria may be included in a different classification when they grade with the APTA criteria and the criteria of Ramos et al.

Circumferential Measurements to Calculate Lower Limb Volume in Persons with Lymphedema: What Segment Length Is to Be Recommended? - click for abstract

Circumferential Measurements to Calculate Lower Limb Volume in Persons with Lymphedema: What Segment Length Is to Be Recommended?

Charlotta Jönsson, Karin Johansson, Maria Bjurberg, Christina Brogårdh. Lymphat Res Biol. 2022 Nov 24
Introduction: Circumferential measurements (CMs) every 4th cm are commonly used to assess lower limb volume (LLV), but fewer measurements would be less time-consuming. The aim of this study was therefore to establish the agreement between LLV measurements derived from CM every 4th cm (V4), 8th cm (V8), and 12th cm (V12), and to evaluate the intrarater test-retest reliability for each of the three measurement methods in persons with lower limb lymphedema (LLL).
Methods and Results: Forty-two persons with unilateral or bilateral LLL were measured twice, 2 weeks apart. Volume measurements for the V4, V8, and V12 methods were derived using CM. The agreement was evaluated using intraclass correlation coefficient (ICC3.1) and Bland-Altman graphs including 95% limits of agreement (LOA). The reliability was evaluated using ICC2.1 and standard error of measurement (SEM%) and smallest real difference (SRD%). The agreement was high for the V4 and V8 methods (ICC 0.999), and for the V4 and V12 methods (ICC 0.998). The graphs revealed slightly higher agreement between the V4 and V8 than between the V4 and V12 methods visualized by the 95% LOA (-117 to 62 and -236 to 132 mL, respectively). For all three measurement methods, the test-retest reliability was high (ICC 0.993-0.995) and the measurement error low (SEM%: 1.2%-1.4% and SRD%: 3.4%-3.8%).
Conclusions: The higher agreement between the V4 and V8 methods than between V4 and V12, and the high test-retest reliability in LLV measurements support the V8 method to replace the V4 method in persons with LLL

Does Fear of Movement Affect Fatigue and Quality of Life in Lower Extremity Lymphedema? - click for abstract

Does Fear of Movement Affect Fatigue and Quality of Life in Lower Extremity Lymphedema?

Cansu Sahbaz Pirincci, Emine Cihan, Pinar Borman, Meltem Dalyan. Lymphat Res Biol. 2022 Dec 29
The aim of our study was to determine the causes of lower extremity kinesiophobia (whether it is biological or psychological) in individuals with lower limb lymphedema (LLL), and to compare the changes in fatigue and activities of daily living with healthy individuals.
Methods: The study included 74 unilateral LLL patients (study group) and 74 individuals (control subjects). Causes of fear of movement were assessed with the Causes of Fear of Movement questionnaire; fatigue, with the Functional Assessment of Chronic Disease Treatment-Fatigue Questionnaire; and quality of life (QoL) with the Lymphedema Quality of Life Questionnaire-Leg.
Results: One hundred forty-eight participants were included in the study, 74 of whom were in the study group and 74 in the control group. 63.5% of the lymphedema patients had primary lymphedema and 36.5% had secondary lymphedema. Fear of movement total score and QoL scores was higher in LLL group than control group. Total fear of movement score and biological subparameter score of fear of movement, fatigue, and some subparameters of QoL scores were found to be higher in primary LLL patients compared with secondary LLL.
Conclusion: Fear of movement is common and QoL is impaired in patients with secondary LLL, more significant in primary LLL.

Current Diagnostic Tools for Breast Cancer-Related Lymphedema - click for abstract

Current Diagnostic Tools for Breast Cancer-Related Lymphedema

Chirag Shah, Wafa Asha, Frank Vicini. Curr Oncol Rep. 2023 Jan 25. doi: 10.1007/s11912-023-01357-w
PURPOSE OF REVIEW: Breast cancer-related lymphedema (BCRL) can have a significant impact on breast cancer survivors quality of life. The purpose of this review is to evaluate diagnostic tools for the assessment of BCRL.
RECENT FINDINGS: Multiple BCRL diagnostic tools are available, though older diagnostic tools have low sensitivity, limiting the ability for sub-clinical BCRL diagnosis while BIS and perometry have increased sensitivity and the ability to diagnose BCRL sub-clinically. Prospective studies have demonstrated such an approach coupled to early intervention is associated with low rates of chronic BCRL while a recently published randomized trial demonstrated that prospective surveillance with BIS coupled with early intervention reduced rates of chronic BCRL as compared to circumference measurements with compression garments. Prospective and randomized data support the use of prospective surveillance for BCRL. The strongest data available comes from the PREVENT trial and supports prospective BCRL surveillance with bioimpedance spectroscopy coupled to early intervention with a compression sleeve.

Early Referral for Breast-Cancer-Related Lymphedema: Do We Follow the Evidence? A Two-Year Prospective Multicenter Cohort Study

Ad A Hendrickx, Saskia W Küthe, Cees P van der Schans, Wim P Krijnen, Chantal M Mouës-Vink, Robert J. Damstra. Cancers (Basel). 2022 Dec 6;14(23):6016.

Download full paper

A qualitative systematic review and meta-aggregation of the experiences of men diagnosed with chronic lymphoedema

Garry R Cooper-Stanton, Nicola Gale, Manbinder Sidhu, Kerry Allen. J Res Nurs. 2022 Dec;27(8):704-732.

Download full paper

Bioimpedance spectroscopy for breast cancer-related lymphedema assessment: clinical practice guidelines

Chirag Shah, Pat Whitworth, Stephanie Valente, Graham S Schwarz, Megan Kruse, Manpreet Kohli, Kirstyn Brownson, Laura Lawson, Beth Dupree, Frank A Vicini. Breast Cancer Res Treat. 2022 Dec 24.

Download full paper

Algorithm-Based Risk Identification in Patients with Breast Cancer-Related Lymphedema: A Cross-Sectional Study

Mauro Nascimben, Lorenzo Lippi, Alessandro de Sire, Marco Invernizzi, Lia Rimondini. Cancers (Basel). 2023 Jan 4;15(2):336.

Download full paper

Management Strategies

Acute Effects of Manual Lymphatic Drainage and Compression with Exercise Therapy on Breast Lymphedema Following Breast-Conserving Surgery and Radiotherapy- click for abstract

Acute Effects of Manual Lymphatic Drainage and Compression with Exercise Therapy on Breast Lymphedema Following Breast-Conserving Surgery and Radiotherapy

Miray Haspolat, Elif Sakızlı Erdal, Burak Erturk, Ozge Petek Erpolat, Ilke Keser. Lymphat Res Biol. 2022 Nov 24
Breast lymphedema is a common complication of breast cancer treatments but there are limited studies about the treatment of breast lymphedema. The aim of this study was to investigate the acute effects of manual lymphatic drainage (MLD), compression with exercise on the local tissue water percentage, pain, and stiffness following breast-conserving surgery and radiotherapy. Materials and Methods: Twenty-two patients (52.54 ± 12.18 years, 28.55 ± 5.11 kg/m2) were included. The sociodemographic and clinical information was recorded. The pain and stiffness severity were measured with Visual Analog Scale. Measurements of water percentages in local tissue were performed in all quadrants of the breast with the Moisture Meter D Compact device. All measurements were performed baseline, after MLD, and after compression with exercise. Results: There was a significant difference in local tissue water percentages between the affected and unaffected sides before treatment. The percentage of water only in the lower outer quadrant of the affected breast increased significantly after acute treatment (p: 0.002). In addition, pain (p: 0.001) and stiffness (p: 0.001) scores decreased. Conclusions: Local tissue water percentages increased with MLD and decreased with compression with exercise. In the treatment of breast lymphedema, MLD and compression bandage with exercise may be beneficial in the management of the symptoms of swelling, pain, and stiffness

Comparison of compression therapy use, lower limb wound prevalence and nursing activity in England: a multisite audit - click for abstract

Comparison of compression therapy use, lower limb wound prevalence and nursing activity in England: a multisite audit

Alison Hopkins, Ray Samuriwo. J Wound Care. 2022 Dec 2;31(12):1016-1028

Objective: This audit was designed to identify the need of the population and the clinical activity associated with wounds and the management of lower limb swelling. The exploration focused on lower leg wound management, access to diagnostics and compression therapy across each audit site. The variation across the sites was explored to gather insight into the real-world barriers to providing evidence-based management for leg ulceration.

Method: We undertook wound prevalence audits across six diverse community provider sites in England. The audit was undertaken by the local providers, with the inclusion of tissue viability and podiatry leads and key local stakeholders, often local quality leads, primary care leads and nursing directors. Each audit was undertaken with full engagement of local clinicians. Data were collected centrally, and each audit site received their own local analysis and report, with additional analytical support from the local tissue viability lead to ensure the feedback was contextualised for their stakeholders. Analysis was provided by Accelerate CIC Lymphoedema & Leg Ulcer Clinic.

Results: A total of 2885 patients were reviewed via an online or a paper audit tool. In total, 2721 patients had one or more active wounds. However, 1350 patients had one or more lower leg wounds, with 164 patients being managed for lower limb swelling or prevention of leg ulceration; bilateral conditions ranged from 11-43% across audit sites. Of the six sites, two included both community and primary care providers, thus generating wound point prevalence data. The remaining four sites audited community nursing and podiatry services only, with two sites collecting data on lower limb wounds only rather than all wounds, generating point prevalence for their services only. Compression usage varied across care locations, with the greatest use being seen in community leg ulcer clinics, where it was >96% for 234 residents. Compression usage was lower in the home with a range of 14-62% among 692 residents. For 263 residents, where the cause of their lower leg wound was unknown, compression usage was very low at 12%. Compression usage decreased with age; for three audit sites this was noteworthy, with 65% of those aged >80 years not in receipt of compression. Compression usage had a direct impact on nursing activity; non-use of compression increased activity by 37%.

Conclusion: Through the identification of wound location, this series of wound prevalence audits identified a greater number of patients with lower limb wounds than those recognised and classified as a leg ulcer. Substantial variation in access to diagnostics and compression therapy was observed between audit sites, and also between locations within their boroughs. The factors that reduced access to compression therapy included not classifying the lower leg wound as a leg ulcer, being cared for in the home and increasing age of the patient. Lack of compression usage increased nursing activity. Where there is lack of access to therapeutic intervention, the resultant patient harm is not systematically recognised or documented.

Use a wrap instead: using compression wraps in lymphoedema and venous disease - click for abstract

Use a wrap instead: using compression wraps in lymphoedema and venous disease

Drew Payne. Br J Community Nurs. 2022 Dec 2;27(12):586-590

Lymphoedema is more than ‘swollen legs’; it is an unpleasant condition that affects approximately 260 000 people in the UK. This article briefly looks at what the lymphatic system is and what lymphoedema is. It then looks at compression wraps and argues for wider use with patients, as they can promote self-care in patients.

The effect of complex decongestive therapy on spatio-temporal parameters and balance in women with breast cancer-related upper extremity unilateral lymphedema - click for abstract

The effect of complex decongestive therapy on spatio-temporal parameters and balance in women with breast cancer-related upper extremity unilateral lymphedema

Furkan Bilek, Gulnihal Deniz, Arif Gulkesen. Clin Biomech (Bristol, Avon). 2023 Jan 13;102:105890.
BACKGROUND: The aim of this study was to investigate the effect of complex decongestive therapy on spatio-temporal parameters and balance in individuals with breast cancer-related upper extremity unilateral lymphedema.
METHODS: The study was designed as a prospective, cross-sectional study. Thirty sessions of complex decongestive therapy were applied. Participants’ pre-and post-treatment spatio-temporal parameters and balance parameters were evaluated with the Win Track platform. In addition, the Timed Up and Go test was used to evaluate the dynamic balance. Plethysmography, a water displacement method, was used to measure upper extremity volume.
FINDINGS: Significant improvement was observed in limb volume asymmetry after complex decongestive therapy. While the stride length of the affected side was 409.93 mm before the treatment, it increased to 500.93 mm after the treatment, and a significant increase was observed (p = 001). Significant improvements were found in the other spatio-temporal parameters of the participants. Compared to the pre-treatment, a significant decrease was detected in the average cadence value, Timed Up and Go value, double stance time, and maximum plantar pressure point of the participants. Significant improvements were found in the participants’ balance.
INTERPRETATION: Complex decongestive therapy applied to individuals with unilateral upper extremity lymphedema provides significant improvement in both spatio-temporal and balance parameters. However, we recommend complex decongestive therapy as an effective and safe treatment to reduce the volume of lymphedema. Patients with unilateral lymphedema that may cause postural asymmetry should be informed about balance and gait disturbance and should be encouraged to receive lymphedema treatment as soon as possible.

Effect of Neural Tissue Mobilization on Sensory-Motor Impairments in Breast Cancer Survivors with Lymphedema: An Experimental Study - click for abstract

Effect of Neural Tissue Mobilization on Sensory-Motor Impairments in Breast Cancer Survivors with Lymphedema: An Experimental Study

Devanshi Joshi, Sakshi Shah, Sandeep B Shinde, Sanjaykumar Patil. Asian Pac J Cancer Prev. 2023 Jan 1;24(1):313-319.
BACKGROUND: Breast surgery, Axillary Lymph Node Dissection (ALND), radiation and chemotherapy may develop several complications such as axillary web syndrome, frozen shoulder, numbness, shoulder pain and range of motion restriction, lymphostasis, and lymphedema. Up to 77% report sensory disturbance in the breast or arm after breast surgery. These short- and long-term consequences have dramatic impact on physical function and quality of life in this population.
AIMS: The aim of the study was to determine the effect of neural tissue mobilization on sensory-motor impairments in breast cancer survivors with lymphedema.
SUBJECTS AND METHODS: This study was carried out by analyzing total 100 breast cancer survivor women, with lymphedema aged between 30-65 years of age who had undergone breast surgery mostly lumpectomy along with chemotherapy or radiation therapy. Participants were divided into two groups by random allocation. One group underwent neurodynamic mobilization and the other group conventional physiotherapy.The treatment protocol was given for 6 weeks. Parameters such ROM, pain, lymphedema and sensory-motor impairments were assessed at the baseline before the treatment and 6 weeks after the treatment.
RESULT: The result from this study shows that there is significant improvement (p<0.0001, t-value 4.69) in mTNS of patients undergoing neural tissue mobilization,whereas there was no significant improvement (p=0.05, t-value 1.951) seen in patients undergoing conventional physiotherapy.
CONCLUSION: This study concludes that effect of neural tissue mobilization has significant impact on sensory motor impairments as compared to conventional treatment protocol in breast cancer survivors with lymphedema.Pain and ROM showed similar difference with both the treatment protocols. It was also observed that patients with mild and moderate lymphedema showed significant improvement as compared to patients with severe lymphedema

Practice patterns of physical therapists and physical therapist assistants treating patients with breast cancer related lymphedema - click for abstract

Practice patterns of physical therapists and physical therapist assistants treating patients with breast cancer related lymphedema

Meredith Wampler, Elizabeth Campione, Charlotte A Bolch. Support Care Cancer. 2023 Jan 26;31(2):134
Clinical Practice Guidelines (CPGs) aim to improve patient outcomes through implementation of proven interventions and decrease variation in practices. The relevance of this article is to describe the current state practice of physical therapists who diagnose and treat patients with Breast Cancer Related Lymphedema (BCRL). It also provides a description of physical therapist-reported adherence to the BCRL CPG recommendations which establishes the need for implementation interventions to improve adherence.PURPOSE: The purpose of this study is to describe practice patterns of physical therapists (PT) and physical therapist assistants (PTA) who treat patients with breast cancer-related lymphedema and determine if they are adherent to best evidence recommendations for lymphedema diagnosis and intervention.METHODS: An electronic survey to collect practice pattern data of PTs and PTAs who treat patients with BCRL was distributed. A descriptive and quantitative statistical analysis was performed.RESULTS: Twenty-six percent of respondents read the American Physical Therapy Association sponsored lymphedema diagnosis clinical practice guideline (CPG) and 20% read the lymphedema intervention CPG. Lymphoscintigraphy was the only diagnosis or intervention tool with a significant difference in use between therapists who read versus did not read the CPGs. Adherence to “should do” recommendations was variable: bioimpedance (18.2%), volume calculation (49.3%), ultrasound (0%), patient reported outcome tools (64.9%), compression garments (43.9%), exercise (87.2%), and compression bandaging (56.8%).CONCLUSIONS: There is variability in adherence to recommendations for both the lymphedema diagnosis and intervention CPGs. Interventions to improve implementation and adherence to CPG recommendations are warranted.

Selecting appropriate compression for lymphedema patients: American Vein and Lymphatic Society position statement

Heather Hettrick, Suzie Ehmann, Brandy McKeown, Dean Bender, John Blebea
Phlebology. 2023 Jan 6:2683555221149619
 

Download full paper

The Randomized Controlled Study of Low-Level Laser Therapy, Kinesio-Taping and Manual Lymphatic Drainage in Patients With Stage II Breast Cancer-Related Lymphedema

Sedef Selcuk Yilmaz, Fikriye Figen Ayhan. Eur J Breast Health. 2023 Jan 1;19(1):34-44. 

Download full paper

Evaluating the cost of managing patients with cellulitis in Wales, UK: A 20-year population-scale study

Ioan Humphreys, Ashley Akbari, Rowena Griffiths, Dave Graham-Woollard, Karen Morgan, Rhian Noble-Jones, Marie E. Gabe-Walters, Melanie J. Thomas. Int Wound J. 2023 Jan 17

Download full paper

Resources

  • All articles

Management Strategies

  • Exercise
  • Compression
  • Motivation
  • Mindfulness

Anatomy, Physiology and Pathophysiology

  • Anatomy
  • Pathophysiology
  • Physiology

Prevalence and Risk Factors

  • Prevalence and Risk Factors

Assessment

  • Assessment

Resources

  • Book Review
  • Document review
  • Hot off the Press
  • New dates
  • New courses
  • News

Resources

  • Chronic Oedema and Wound Care: A Critical ConnectionSeptember 3, 2025 - 10:00 am
  • Hot of the Press September 2025September 1, 2025 - 10:44 am
  • Supporting the Management of Leaky Legs: A Clinical GuideSeptember 1, 2025 - 8:45 am
  • Understanding and Applying IPC in Lymphoedema Management Part 2August 21, 2025 - 5:23 am
  • Introducing the LES Podcast: Lymphoedema Insights for Health ProfessionalsAugust 6, 2025 - 1:35 pm
  • LMS Login
© Copyright - Lymphoedema Education Solutions - site by Black Mouse Design
  • Home
  • Courses
  • About
  • Upcoming dates
  • Contact
Chronic oedema in the ageing population – Part 1Let’s Face the Elephant in the Room
Scroll to top