Objective: The conservative treatment of post-thrombotic syndrome includes application of compression on the affected extremity. However, the type and the level of compression required to manage post-thrombotic syndrome are still unclear. The aim of our proof-of-concept study was to assess the compression required to reduce cross section area of post-thrombotic deep veins in 22 patients with post-thrombotic syndrome.
Methods: The circumference and cross section area of posterior tibial veins and saphenous vein trunk were assessed on mid-calf level using 3T magnetic resonance scanner, at increasing compression (0, 30, 40, and 50mmHg), provided by a novel adjustable Velcro compression wrap, the CircAid JuxtaLiteV R .
Results: A significant reduction of baseline vein cross section area in post-thrombotic syndrome patients in the lying position required compression of at least 30mmHg for posterior tibial veins, and at least 40mmHg for the saphenous trunk. Apart from morphological changes of the compressed veins, we observed extinction of T2w signal at compression above 40mmHg, which corresponded to accelerated blood flow in the veins, and therefore may be considered as a hemodynamic marker of compression effectiveness.
Conclusion: CircAid adjusted to compression level 40mmHg accelerates blood flow in affected deep veins, thus it may facilitate post-thrombotic syndrome management.