Main findings

• To the authors knowledge, this is the first systematic literature review summarizing studies about the use of pharmacotherapy agents in lymphedema treatment. Different drugs that act by immunologic modulation were proposed. The rationale is that lymphangiogenesis could be potentiated by removing the deleterious manifestations of inflammation.
• Promising outcomes were reported for the utilization of ketoprofen, selenium, and tacrolimus. Those agents were easily delivered and well-tolerated by patients and have the advantage of not increasing the risk of metastasis.