Hot of the Press February 2026
Article to ponder
This systematic review of five randomized controlled trials (1004 participants) examined whether prophylactic compression sleeves prevent breast cancer–related lymphedema after axillary surgery. The review found no significant reduction in lymphedema incidence with sleeve use compared with standard care, although some studies reported small, inconsistent reductions in early arm swelling. Evidence quality was low due to heterogeneity, variable adherence, and risk of bias, and no sustained quality-of-life benefits were demonstrated
Compression sleeves for prevention and treatment of breast cancer-related lymphedema: a systematic review and meta-analysis
Key Takeaway: Prophylactic compression sleeves do not meaningfully reduce the incidence of breast cancer–related lymphedema, although they may confer small, short-term reductions in arm swelling, based on low-certainty evidence.
We have collated some great articles and material published over the last month. Click on the links below to read the abstract or download the full paper.
Anatomy / Physiology /Pathophysiology
Ultrasonographic Evaluation of Distal Femoral Cartilage Thickness in Patients with Lower Extremity Lymphedema - click for abstract
Ultrasonographic Evaluation of Distal Femoral Cartilage Thickness in Patients with Lower Extremity Lymphedema
The Upper Arm Lymphosome: Watershed of Upper Arm Lymphatic Pathways Evaluated with Indocyanine Green Lymphography - click for abstract
The Upper Arm Lymphosome: Watershed of Upper Arm Lymphatic Pathways Evaluated with Indocyanine Green Lymphography
Definition, Epidemiology and Pathophysiology of Lymphoedema
Indocyanine Green Lymphography Imaging of Normal Lymphatic Drainage in the Lower Limbs
Prevalence and Risk Factors
Patients With Lymphedema are at Increased Risk of Complication After Total Knee Arthroplasty: A Population Level Study
Nomogram for predicting risk of arm lymphedema following axillary lymph node dissection in breast cancer patients
Machine learning-based personalized risk prediction model for breast cancer-related lymphedema after surgery
Limb swelling consistent with posttraumatic lymphedema after closed upper and lower extremity fractures: A retrospective cohort study
Prevention of arm lymphoedema after breast cancer: what health professionals need to know - click for abstract
Prevention of arm lymphoedema after breast cancer: what health professionals need to know
Why It Matters
- Arm lymphoedema occurs in ~20% of breast cancer patients after surgery or radiotherapy.
- It significantly impacts quality of life, increases risk of cellulitis, and leads to higher healthcare utilization.
- Psychological burden includes negative self-identity and social isolation.
Prevention and Early Detection
- Lymphoedema is preventable and reversible if detected early.
- Monitoring every 3–6 months for 2–3 years post-treatment reduces incidence.
- Tools: bioimpedance spectroscopy or circumferential measurements.
- Education on lifestyle changes and self-management strategies is critical.
Risk Factors
- Baseline risk:
- High risk: Full axillary clearance ± radiotherapy (up to 38.7% incidence).
- Medium risk: Partial clearance or targeted axillary radiotherapy (~11%).
- Low risk: Sentinel node biopsy (<5 nodes removed, ~5.6%).
- Additional treatment factors: infections, seromas, cording, mastectomy, chemotherapy ports, hormonal therapy.
- Lifestyle factors: high BMI, sedentary lifestyle, injuries, inflammation.
Updated Advice
- Exercise, including resistance training, is now recommended (activates muscle pump).
- Avoid unnecessary restrictions; encourage normal arm use.
- Prevent cuts, burns, bites; maintain skin care to reduce cellulitis risk.
Preventative Strategies (Table 3)
- Arm exercises and general physical activity.
- Maintain healthy weight.
- Deep breathing exercises.
- Mobilise and stretch tight scars.
- Treat cording promptly.
- Use compression sleeves as needed.
- Good skin care and moisturising.
- Prepare for long-haul flights (movement, hydration, optional sleeve).
Role of Community Health Professionals
- Provide lifetime education for medium/high-risk patients.
- Reinforce advice at multiple time points (due to stress and poor retention).
- Empower patients to self-monitor and self-manage early swelling episodes.
Key Takeaways
- Arm lymphoedema is preventable and reversible if caught early.
- Education and monitoring are central to prevention.
- High- and medium-risk patients need ongoing support and self-management skills.
- Community professionals play a critical role in prevention and early intervention.
A Latent Profile Analysis of Risk Perception in Breast Cancer-Related Lymphedema Among Women With Breast Cancerw - click for abstract
A Latent Profile Analysis of Risk Perception in Breast Cancer-Related Lymphedema Among Women With Breast Cancer
Assessment
Assessing Tissue Dielectric Constant Values in Tumor Bearing and Healthy Breasts - click for abstract
Assessing Tissue Dielectric Constant Values in Tumor Bearing and Healthy Breasts
Background: This study aimed to investigate, characterize, and provide quantitative reference data on tissue dielectric constant (TDC) values of female breasts when measurements were made to 5 mm depths and determine the utility of these measurements to differentiate between benign and malignant breast tumors.
Methods and Results: Breast TDC was measured bilaterally in 82 women just prior to an ultrasound-guided diagnostic biopsy of one tumor in one breast. TDC was measured in triplicate over the tumor and the contralateral healthy breast. Considering all paired breasts, the average TDC (mean ± SD) for healthy breasts was less than for tumor-bearing breasts (26.7 ± 4.5 vs. 29.9 ± 8.5, p = 0.0003).
Conclusions: Breast TDC values measured to 5 mm in 82 healthy nonedematous breasts provide a two-SD threshold reference value of 35.7. This represents a TDC value above which the presence of breast edema/lymphedema may be indicated based on the two-SD threshold criterion. For unilateral cases, an interbreast TDC ratio exceeding 1.275 may be considered a breast edema/lymphedema indicator also based on the two SD criteria used. These thresholds may have utility for early detection and to track breast edema/lymphedema changes. A comparison of these TDC values obtained from benign versus malignant tumors indicates no statistically significant difference between them. However, interbreast TDC ratios were statistically higher for breasts with malignant versus benign tumors. However, the large overlap of the ratio values renders this method of discrimination between benign vs. malignant tumors inadequate based on the present findings.:10.1089.0061
Hyperspectral imaging as an objective diagnostic tool for secondary lymphedema in breast cancer patients
Impact of Breast Cancer-Related Lymphedema on Cancer Care Costs: Longitudinal and Age-Based Analyses
Inter-breast Ratios of Tissue Dielectric Constant Values to Detect and Track Unilateral Breast Edema or Lymphedema
Management Strategies
Finite Element Modeling of Compression Therapy in Lower Limb Lymphedema - click for abstract
Finite Element Modeling of Compression Therapy in Lower Limb Lymphedema
Effects of Aerobic Exercise with Manual Lymphatic Drainage in Chronic Venous Insufficiency Patients- click for abstract
Effects of Aerobic Exercise with Manual Lymphatic Drainage in Chronic Venous Insufficiency Patients
Compression sleeves for prevention and treatment of breast cancer-related lymphedema: a systematic review and meta-analysis- click for abstract
Compression sleeves for prevention and treatment of breast cancer-related lymphedema: a systematic review and meta-analysis
Cancer-related lymphedema educational needs disparities and optimization strategies - click for abstract
Cancer-related lymphedema educational needs disparities and optimization strategies
Effect of Advanced Pneumatic Compression Devices in the Treatment of Lymphedema: A Systematic Review and Meta-Analyses - click for abstract
Effect of Advanced Pneumatic Compression Devices in the Treatment of Lymphedema: A Systematic Review and Meta-Analyses
From Mobility to Management: A Scoping Review on Exercise in Breast Cancer-Related Lymphedema - click for abstract
From Mobility to Management: A Scoping Review on Exercise in Breast Cancer-Related Lymphedema
Outcomes after liposuction-based treatment of lymphedema: a systematic review and meta-analysis
Effect of home exercise on prevention and treatment of lymphedema in breast cancer patients
A co-design of a digital platform to support self-management of breast cancer-related lymphoedema
The effect of prolonged complex decongestive therapy for lower limb secondary lymphedema
The effects of adding physiotherapy to compression therapy on function and oedema in chronic venous insufficiency
Self-management of lower limb lymphedema at home following gynecologic cancer surgery: a qualitative study of women’s experiences and challenges
Short-Term Outcomes of Advanced Pneumatic Compression Device Versus Usual Care Therapy for Head and Neck Cancer-Related Lymphedema: A Multi-Site Randomized Clinical Trial
The efficacy of complex decongestive therapy in the treatment of lymphedema associated with endometrial and cervical cancer: evaluation of sensation and balance




